Hotels have safes for a reason, before the event pretty much lock up everything of value, you really have no clue who this girl is, so don't take any chances. If the safe is too small for your laptop, consider putting it in a rarely checked location (such as under the bed or high in the closet between hotel supplies like extra pillows or stuff like that). You may also want to lock your suitcase (and if you took your clothes out of the suitcase, you can lock your carry on back inside the suitcase, with your laptop bag, etc. It makes it less obvious that you have the stuff to start with. Only keep enough money out to pay for the punt, otherwise keep the rest under lock.
Oh yeah, if you have a locking in room bar (need a key to access) don't advertise where the key is and certainly don't leave it out. That shit is expensive!
Basically, the only time you go into the locked safe is as the girl is leaving, in case you need extra cash for a tip or to pay some sort of odd extra you agreed to.
Play safe, and things will go well.